706. Consistent Viral Vector Manufacturing for Phase III Using iCELLis 500 Fixed-Bed Technology
نویسندگان
چکیده
منابع مشابه
Viral vector production in the integrity® iCELLis® single-use fixed-bed bioreactor, from bench-scale to industrial scale
Introduction Wild-type or recombinant viruses used as vaccines and human gene therapy vectors are an important development tool in modern medicine. Some have demonstrated high potential such as lentivirus, paramyxovirus and adeno-associated-virus (AAV). These vectors are produced in adherent and suspension cell cultures (e.g. HEK293T, A549, VERO, PER.C6, Sf9) using either transient transfection...
متن کاملProgress and challenges in viral vector manufacturing.
Promising results in several clinical studies have emphasized the potential of gene therapy to address important medical needs and initiated a surge of investments in drug development and commercialization. This enthusiasm is driven by positive data in clinical trials including gene replacement for Hemophilia B, X-linked Severe Combined Immunodeficiency, Leber's Congenital Amaurosis Type 2 and ...
متن کاملLinear scalability of virus production in the integrity® iCELLis® single-use fixed-bed bioreactors from bench to industrial scale
Introduction In order to maximize cell growth within a compact space and retain cells for easy medium exchange, the iCELLis bioreactors from ATMI LifeSciences contain macro-carriers trapped in a fixed-bed, creating a 3-D matrix within which cells adhere and replicate. These bioreactors also enable precise temperature, pH and dissolved oxygen control which cannot be done in 2-D cultures. The iCE...
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Studies on bench scale reactors packed with two different media matrix – Biopac media and Fugino spirals were undertaken to determine the performance at various organic loading rate (OLR) and on one day hydraulic retention time (HRT). Parboiled rice mill wastewater depicted a COD/BOD ratio of 1.6 indicating good degradable nature of the wastewater. Four different organic loadings of 0.8, 1.6, 2...
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The Solar Vector Magnetograph (SVM) is a modern imaging spectropolarimeter installed at Udaipur Solar Observatory (USO). Earlier phases saw the development of the instrument using off-the-shelf components with in-house software development. Subsequently, improvements were done in the opto-mechanical design of the sub-systems and the telescope tracking system. The third phase of the instrument d...
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2016
ISSN: 1525-0016
DOI: 10.1016/s1525-0016(16)33514-6